do-notation can be easily implemented using delimited continuations (ie. generators). Generators compose well and flatten tail calls so you don't need TCO or trampolines. The only notable issue is that one-shot delimited continuations like generators don't work with non-deterministic monads (ie. List). Multi-shot can be emulated by keeping a cache of past values and replaying the generator, but performance will suffer. See burrido [1] for a JavaScript do-notation implementation.
[1] https://github.com/pelotom/burrido