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Comment by XFrequentist

Agree that it's a poor headline and that the fructose/Alzheimer's hypothesis is quite speculative, but I don't think calling it a "junk study" or gesturing at evidence hierarchies is particularly helpful.

Theory (almost) always precedes evidence, and coming up with a novel, biologically-plausible explanation for a common ailment is absolutely a valid, useful scientific contribution.

Your general point, that drawing firm conclusions would be radically premature, is spot on. I just stiffen up a bit when I encounter "RCT or GTFO" type arguments; where in the world do you think the ideas for which RCT to run come from?

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