Comment by NewMountain

I too hate them and don't want anything optimized for minute long content.

This is a kind of fun game of whack-a-mole, but here is my current ruleset for uBlock Origin:

    www.youtube.com###guide-content #endpoint[title="Shorts"]:upward(ytd-guide-entry-renderer)
    www.youtube.com###items #endpoint[title="Shorts"]:upward(ytd-mini-guide-entry-renderer)
    www.youtube.com##ytd-browse ytd-grid-video-renderer:has(span.ytd-thumbnail-overlay-time-status-renderer[aria-label="Shorts"])
    www.youtube.com##ytd-browse ytd-rich-item-renderer:has(span.ytd-thumbnail-overlay-time-status-renderer[aria-label="Shorts"])
    www.youtube.com##ytd-search ytd-video-renderer:has(span.ytd-thumbnail-overlay-time-status-renderer[aria-label="Shorts"])
    www.youtube.com##ytd-watch-next-secondary-results-renderer ytd-compact-video-renderer:has(span.ytd-thumbnail-overlay-time-status-renderer[aria-label="Shorts"])