In response to the multiple people asking if base editing and CRISPR are the same, the answer is: not quite. Same idea, different enzyme.
The enzyme used by CRISPR is Cas9 (which is why you'll often see it referred to as CRISPR-Cas9), which acts like a pair of molecular scissors and cuts strands of DNA at a specific point in the genome.
Base editing is a newer technique and utilizes an enzyme called deaminase, which can change the chemical structure of a base pair without doing the "cutting" part. There are specific deaminases based you use depending on which base pair you're trying to modify.
To oversimplify a bit: base editing is a more precise version of CRISPR, which is less likely to cause more changes than actually desired, as is a problem with CRISPR. That doesn't make CRISPR obsolete though, because if your goals actually is to remove entire portions of a genome, CRISPR is a more effective technique. Regardless, there is a lot of overlap between the methods: both usually use adenoviruses as the delivery vehicle, you can use both enzymes in tandem, etc.
The enzyme used by CRISPR is Cas9 (which is why you'll often see it referred to as CRISPR-Cas9), which acts like a pair of molecular scissors and cuts strands of DNA at a specific point in the genome.
Base editing is a newer technique and utilizes an enzyme called deaminase, which can change the chemical structure of a base pair without doing the "cutting" part. There are specific deaminases based you use depending on which base pair you're trying to modify.
To oversimplify a bit: base editing is a more precise version of CRISPR, which is less likely to cause more changes than actually desired, as is a problem with CRISPR. That doesn't make CRISPR obsolete though, because if your goals actually is to remove entire portions of a genome, CRISPR is a more effective technique. Regardless, there is a lot of overlap between the methods: both usually use adenoviruses as the delivery vehicle, you can use both enzymes in tandem, etc.