> Furthermore, long-term achievement of diabetes remission, adherence to the diet, and weight loss maintenance after the diet remain a challenge. Studies have also suggested that physiological and metabolic adaptation of the body in response to caloric restriction may shift energy balance and hormonal regulation of weight toward weight regain after weight loss [67,68]. Thus, it is crucial that future studies are directed towards assessing the long-term sustainability of diabetes remission led by LCD and feasibility of this diet on the physiological adaptation and body composition changes.
The basic problem, which has been unchanged for decades, is that hardly anyone actually follows the "proper" diet on a long-term basis without some kind of surgical or drug treatment. Despite weight loss being a massive industry and a very common goal, researchers routinely struggle to find study subjects who have maintained significant long-term weight loss without medical interventions, to the point that there's a special registry to keep track of such people for scientific purposes [1].
The basic problem, which has been unchanged for decades, is that hardly anyone actually follows the "proper" diet on a long-term basis without some kind of surgical or drug treatment. Despite weight loss being a massive industry and a very common goal, researchers routinely struggle to find study subjects who have maintained significant long-term weight loss without medical interventions, to the point that there's a special registry to keep track of such people for scientific purposes [1].
[1] http://www.nwcr.ws/