The holy grail of sugar substitution is ironically sugar. The left-handed isomer of glucose still hits our taste buds but doesn't get metabolized in the body. It just goes straight through. We've tried it before and it worked absolutely perfectly but to synthesize and then separate the isomers was prohibitively expensive.
Whoever finds a way to make left-handed glucose economically is going to be fucking rich.
Whoever finds a way to make left-handed glucose economically is going to be fucking rich.