Comment by somebodynew

In general, it would be difficult to tell with an incomplete patient history whether a psychiatrist prescribing pramipexole for depression was making an irresponsible shot in the dark, or a calculated attempt to address something like treatment-resistant anhedonic depression after a few first lines, an MAOI, and referrals to an endocrinologist and a sleep study failed. That being said, I cannot think of any reasonable scenario that leads to simultaneously prescribing pramipexole and mood stabilizers. Perhaps it's too idealistic of me to hope that the pharmacist filling all three of those (plus two controlled substances...) would have called and asked for an explanation.