> On the other hand, we report that after pre-exposure to mRNA-LNPs, the resistance of mice to heterologous infections with influenza virus increased while resistance to Candida albicans decreased.
It sounds to me as though the tradeoff being made here is: a slightly decreased immune response generally, but a better immune response to the thing you've been immunized against. That seems to be a reasonable tradeoff if there's something really bad going around.
But as they say in the paper summary: more research is needed.
Also: this is purely in mice. They have zero data on whether this is true for humans.
It sounds to me as though the tradeoff being made here is: a slightly decreased immune response generally, but a better immune response to the thing you've been immunized against. That seems to be a reasonable tradeoff if there's something really bad going around.
But as they say in the paper summary: more research is needed.
Also: this is purely in mice. They have zero data on whether this is true for humans.