Comment by npilk

Though unfinished, I highly recommend the Pale King. It's not as consistently great as some of DFW's other works, but the highs are as high as anything else he wrote and IMO it's a little more accessible than Infinite Jest. (For a new reader, I would start with some of his essays, e.g. Consider the Lobster: http://www.columbia.edu/~col8/lobsterarticle.pdf)