Comment by tokai

Problematizing the serotonin hypothesis is nothing new. I'm disappointed that this is not a new study but just a meta review. It does nothing to resolve the issue with serotonin levels not causing depression while antidepressants have a proven (slight) positive effect on depressive symptoms. It also doesn't do anything for explaining the effects from antidepressants that affect other things than serotonin. Like sertraline with its dopaminergic effect.