https://vitejs.dev/ for packaging - I got really grumpy when frontend stuff started needing build and packaging tools, but it's the nature of things so you just have to deal with it, and vite is fast, not overly complicated, and supports fast hot reloading.
For layout, don't use any CSS framework, but instead refer to https://css-tricks.com/snippets/css/a-guide-to-flexbox/ often - every time I use some big CSS framework I end up fighting it at some point.
https://vitejs.dev/ for packaging - I got really grumpy when frontend stuff started needing build and packaging tools, but it's the nature of things so you just have to deal with it, and vite is fast, not overly complicated, and supports fast hot reloading.