Comment by dmcgee

Not that replace standard brushing, but I worked with a company in Denmark called Novozymes. They produce enzymes for a variety of applications including dental care. They have a set of enzymes that they license to Unilever for a toothpaste called Zendium, which has some market share in Northern Europe. The enzymes break down microfilm that develops on teeth, making brushing more effective. There was RCT done on it I believe, I read the paper years ago, can't seem to find it now though.