Comment by killjoywashere

As a pathologist, good luck. The problem with early detection is getting enough signal. These liquid biopsies have historically worked for large occult tumors that are spilling a bunch of DNA. They won't work for in situ tumors, almost by definition. Maybe some really agro DCIS, but generally if the tumor hasn't broken across the basement membrane, you're going to have a hard time getting signal in the blood stream. Contradictory evidence is most welcome.