The amyloid hypothesis is such utter bullshit, at this point there have been empirically effective anti-amyloid plaque drugs. That is drugs that effectively and measurably reduce amyloid plaque build up. None of those drugs have impacted Alzheimers symptoms in any way.
If you have a hypothesis of the cause of a disease, and you create drugs that effectively treat it, and those drugs don’t effect the disease symptoms or progression you need to accept the hypothesis is wrong.
If you have a hypothesis of the cause of a disease, and you create drugs that effectively treat it, and those drugs don’t effect the disease symptoms or progression you need to accept the hypothesis is wrong.