Comment by Hnrobert42

The fact that leptin, not food, restored high-power mode makes me wonder if we could use leptin to increase dieting efficacy. I’ve read that there are limits to how much weight you can lose per week, no matter how much you restrict your caloric intake. Beyond a certain point, your body senses the deficiency and decreases your metabolism. If a person could restrict calories AND receive leptin injections, they could lose weight faster. (note, I am thinking about this in terms of helping the morbidly obese in dire circumstances.)