The world of medecine is degenerate. Sustainable, non addictive and non neurotoxic anxiolytics exists:
the #1 being opipramol the sigmaergic.
emoxypine (which btw cure hangover) and guanfacine are worth mentioning.
Maybe beta blockers to some extent. NMDA antagonists such as memantine have side effects but are not neurotoxic to my knowledge and there are milder ones such as mg-lthreonate.
afobazole is interesting but its pharmacology is too weird to be sure. Etifoxine is revolutionnary, it double axon length growth rate so ironically a great cure to benzo neurodamage. its acts on the
mitochondria benzodiazepine receptor. It's unclear to me wether it is subject to a tolerance effect and if so if it is lower. Also etifoxine can interact badly with other drugs on the liver.
Note that there exists ultra-atypical mechanisms, such as inositol megadose or tofisopam but they are not firstline.
So yeah, basically opipramol and guanfacine should be what humans take as first line. Glycine is a nice obvious augmentation (kinda absurd that people forget about the second inhibitor neurotransmitter in the brain, especially since the effect feel nice and doesn't really lead to tolerance).
if you have benzo neurodamage, take magnesium lthreonate which is a very potent synaptotrophic.
also fun fact: the benzo cartel was so strong it was the most prescribed drug in the world, all classes, in the 70s
So yeah, basically opipramol and guanfacine should be what humans take as first line. Glycine is a nice obvious augmentation (kinda absurd that people forget about the second inhibitor neurotransmitter in the brain, especially since the effect feel nice and doesn't really lead to tolerance). if you have benzo neurodamage, take magnesium lthreonate which is a very potent synaptotrophic.
also fun fact: the benzo cartel was so strong it was the most prescribed drug in the world, all classes, in the 70s