Comment by anaisbetts

Well I mean, at the end of Shulgin's life he had heart valve damage requiring surgery (psychs cause 5-HT2B agonism which can cause heart valvulopathy), advanced dementia, and liver cancer, all three of which are likely consequences of taking psychedelics frequently. It isn't to say that there aren't benefits to taking these drugs in moderation, but if you're looking for a "Why Not", that's definitely something to think about.