I’m not a JS developer, so take this with much salt, but one that caught my eye was SciterJS [1]. It is built using Fabrice Bellard’s QuickJS engine [2], and appears to be very efficient. Definitely has great potential I think. See previous discussion here: [3]
[1] https://github.com/c-smile/sciter-js-sdk
[2] https://bellard.org/quickjs/
[3] https://news.ycombinator.com/item?id=24797423