Ask HN: What is your preferred “full-stack in a box” solution and why?

What I mean by a "full-stack in a box" is a web client solution + server solution + DB solition that all work well together for a small to medium size business. Minimizing integration friction and maximising productivity. Is it Typescript/C#/Postgress? Elm/Haskell/MySQL? Clojurescript/Clojure/Datomic? Ruby on Rails/? Or something else entirely?