Ask HN: At what point do we agree we are fucking up reality?

If you grew up in the 80s, Cyberpunk was a part of your culture:

Wouldn't it be cool if...

- We could implant nano-bots that augment [X]

- We could change DNA to surmount [THING]

- We could change resistance to [THING]

- We could do [ETC]

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We are here, we built this. We have achieved [THING]

Where stop? Why? Why not?