The public policy responses to this pandemic would make a whole lot more sense if intramuscular (humoral) vaccination actually prevented (or even significantly mitigated) the spread of sars-cov-2. Unfortunately humoral vaccination only starts the B cell to plasma cells training and generation of igG antibodies in the body serum to protect internal organs. Other immune compartments like the upper respiratory mucosa are not protected by serum igG antibodies. And the T cells trained by intramuscular vaccination are not tissue resident in the upper respiratory where they are needed to stop infection. They just do a pretty darn good job at preventing serious disease.
I wish governments of the world would heavily invest in the current and future intranasal sars-cov-2 boosters to prevent spread and follow up on the strong base of intramuscular body protection. I might not even be opposed to mandating intranasal vaccinations since they would stop spread. But this? This doesn't make a lot of scientific sense.
I wish governments of the world would heavily invest in the current and future intranasal sars-cov-2 boosters to prevent spread and follow up on the strong base of intramuscular body protection. I might not even be opposed to mandating intranasal vaccinations since they would stop spread. But this? This doesn't make a lot of scientific sense.