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Comment by AshamedCaptain

> But at the same time, I can patch the Python interpreter and then have some software running on my system actually use the patched version, since all of this stuff is configured through the same configuration system.

If I want to do that, then I have to rebuild the entire system so as to use my patched version. This is because the NixOS "dependencies" are basically expressed as hashes of binaries.

That is for me the single biggest deal-killer of NixOS, Guix, and while we're at it -- static linking.

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