Another fun thing you can do is install Hammerspoon as your URL handler, and make certain URLs open in different Chrome profiles--any work websites open in my work Chrome profile, websites related to a game I play opens in a Chrome profile specific to that, and anything else opens up in a personal Chrome profile.
I've also setup cmd+shift+1/2/3 to brings the aforementioned profiles into the foreground, so e.g. cmd+shift+2 brings my work Chrome profile to the foreground.
I've also setup cmd+shift+1/2/3 to brings the aforementioned profiles into the foreground, so e.g. cmd+shift+2 brings my work Chrome profile to the foreground.