When I ran multiple monitors I often designated one as my "communication" display, which got email/chat on it, and probably browser as well (for reference material), while the other was the active work one with the current task (usually a few terminals). I found the clearly defines areas for specific tasks was useful.
Now I work off a 40" 4k TV without magnification (I'm close to it), and I try to do similar but it's a lot more haphazard. I find that once you have a wall of pixels in front of you, putting stuff in areas helps, but it's also nice to just throw stuff around and treat it as a actual physical desktop (as it's actually about the size now).
The thing to keep in mind is that as screens get larger, maximizing to fill the whole screen makes less and less sense. I can't even see all my screen at once. I could place it farther back and scale it up, but why would I just by a smaller screen and keep it closer then? I want those pixels. I run all my browser windows at about a quarter screen size, and have that app scaled up to 125% (but not all apps), and that almost never has a problem with a site, and I have other info I care about quick saccade away.
Now I work off a 40" 4k TV without magnification (I'm close to it), and I try to do similar but it's a lot more haphazard. I find that once you have a wall of pixels in front of you, putting stuff in areas helps, but it's also nice to just throw stuff around and treat it as a actual physical desktop (as it's actually about the size now).
The thing to keep in mind is that as screens get larger, maximizing to fill the whole screen makes less and less sense. I can't even see all my screen at once. I could place it farther back and scale it up, but why would I just by a smaller screen and keep it closer then? I want those pixels. I run all my browser windows at about a quarter screen size, and have that app scaled up to 125% (but not all apps), and that almost never has a problem with a site, and I have other info I care about quick saccade away.