I think the most obvious redesign would be to switch to a stenography system instead of Querty/Dvorak/etc. By chording, we could type faster with less movements. Steno takes longer to learn, but it's easier to type over 200WPM.
On the other hand, I tried using Plover for a couple months and found it was much better for writing English than it was for programming in an IDE. I missed the function keys. Plover was also a pain to use...I've been meaning to program a Raspberry Pi to run Plover but act like a normal USB or Bluetooth keyboard. I bought the Pi and a small screen, but never got further with the project. The Pi is now the piano synthesizer for my 25 year old music keyboard.
On the other hand, I tried using Plover for a couple months and found it was much better for writing English than it was for programming in an IDE. I missed the function keys. Plover was also a pain to use...I've been meaning to program a Raspberry Pi to run Plover but act like a normal USB or Bluetooth keyboard. I bought the Pi and a small screen, but never got further with the project. The Pi is now the piano synthesizer for my 25 year old music keyboard.