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Comment by sniperjoe360

Radiation oncologist here, the radiation dose delivered (32Gy whole brain in 1.6Gy BID) with boost to tumors is highly unusual and outdated. It causes short term memory loss at a higher rate than stereotactic radiosurgery - which is the preferred standard of care for unresectable BM if the disease is limited.

Stereotactic radiosurgery regularly achieves control rates >70% without any radiosensitizers.

That said, solid work, and bravo if L-Arginine works. Next most obvious work would be to test in stereotactic radiosurgery.

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