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Comment by Ice_cream_suit

Renaissance Technologies is rumoured to use methods from topological quantum field theory.

They are fiercely and aggressively secretive, so no one really know for sure.

However, their founder worked in that field before moving to business: https://en.wikipedia.org/wiki/Chern%E2%80%93Simons_theory

Famously, he was sacked by the NSA for giving an interview opposing US involvement in the Vietnam war.

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