Which is why we need "intelligent design" to "help" the virus jump over this combinatorial problem.
For example we can try spikes from different related viruses, or pick and choose various other tricks, like furin cleavage sites, for example like in this rejected 2018 EcoHealth coronavirus research DARPA grant proposal:
For example we can try spikes from different related viruses, or pick and choose various other tricks, like furin cleavage sites, for example like in this rejected 2018 EcoHealth coronavirus research DARPA grant proposal:
https://twitter.com/JamieMetzl/status/1439989291858513929