My, admittedly limited, understanding is that the immuno response to a natural infection is "broader" and targets more of the viral proteins ("we show that multiple neutralizing epitopes, within and outside the receptor binding domain (RBD), are variably targeted by human polyclonal antibodies") while the vaccine only introduces a single or small number of proteins for the immune system to respond to.
If that is the case then we would want vaccines that include more mRNA instructions for creating more unique viral proteins to expand the number our immune system has been exposed to. I have no idea how challenging that is.
If that is the case then we would want vaccines that include more mRNA instructions for creating more unique viral proteins to expand the number our immune system has been exposed to. I have no idea how challenging that is.