There is not strong evidence supporting a 3rd booster dose in immunocompetent people. We have partly seen a misinterpretation of the Israeli data [1] and specifically the single low effectiveness value that appears to be the result of Simpson's Paradox [2]. Dr. Fauci reported this single value decline from the high nineties to the high seventies on Andy Slavitt's podcast [3]. Pfizer's CEO has promoted this same data, Israel's 3rd dose campaign is well under way, and Fauci's public statements are a strong indicator that the U.S. will follow the same path. British Columbia's Dr. Bonnie Henry indicated yesterday [4] that the Canadian numbers do not yet support a general 3rd dose booster but, like the UK, a longer 2nd dose interval due to a First Doses First (FDF) strategy may be a factor.
The 3rd dose is safe and will probably provide a small benefit to the recipient as Shane Crotty described in TWiV 802 [5]. The downside is that these doses are in short supply globally where they could make a significant difference.
The 3rd dose is safe and will probably provide a small benefit to the recipient as Shane Crotty described in TWiV 802 [5]. The downside is that these doses are in short supply globally where they could make a significant difference.
[1] https://www.covid-datascience.com/post/israeli-data-how-can-...
[2] https://en.wikipedia.org/wiki/Simpson%27s_paradox
[3] https://lemonadamedia.com/podcast/dr-fauci-answers-your-bigg...
[4] (YouTube ~3.5min @36m45s) https://youtu.be/93Rnjmr7iCk?t=36m45s
[5] https://www.microbe.tv/twiv/twiv-802/