The cited source does not support the stated proposition. Your link says 335,000 civilians, and it counts all deaths, not just those caused by the U.S.
I was directly involved in U.S. CIVCAS mitigation measures in a Daesh convoy engagement by U.S. air power in the summer of 2016. I cannot comment on anything that transpired within the classified space. However, there was substantial reporting on the discrepancy between the measures implemented by U.S. drone strikes during the engagement, and measures implemented by Iraqi helicopters during the engagement. I encourage you to think about what that discrepancy might mean, if true, about how you're using those numbers.
I was directly involved in U.S. CIVCAS mitigation measures in a Daesh convoy engagement by U.S. air power in the summer of 2016. I cannot comment on anything that transpired within the classified space. However, there was substantial reporting on the discrepancy between the measures implemented by U.S. drone strikes during the engagement, and measures implemented by Iraqi helicopters during the engagement. I encourage you to think about what that discrepancy might mean, if true, about how you're using those numbers.