Calorie in/ calorie out is reasonable if you start counting the calorie effectively absorbed by your gut (the “IN”), and find a way to measure the energy spent by your body in all directions (including temperature keeping, brain activity, etc., the “OUT”).
The killing joke being that the “OUT” has been times and times shown to be regulated depending on the “IN”, so reduction in calorie intake generally cascades in reduced calorie spending in a variety of ways.
The killing joke being that the “OUT” has been times and times shown to be regulated depending on the “IN”, so reduction in calorie intake generally cascades in reduced calorie spending in a variety of ways.