I'm impressed and grateful that DeepMind released this resource, this will save a lot of compute from labs trying to replicate an entire exome for themselves. While some structures look great, there are still some misses here. Important structures like BRCA1 (a well-studied breast cancer associated protein) are just structures for the BRCT and RING domains surrounded by a low-confidence string of amino acids, likely shaped to be globular: https://alphafold.ebi.ac.uk/entry/P38398
Maybe I was wrong for expecting the impossible here, but I was excited to see this specific structure and it appears that there is still work to do. Nevertheless, kudos to Deepmind on their amazing achievement and contributions to the field!
Maybe I was wrong for expecting the impossible here, but I was excited to see this specific structure and it appears that there is still work to do. Nevertheless, kudos to Deepmind on their amazing achievement and contributions to the field!