Comment by couteiral

I respectfully disagree. AlphaFold 2 demonstrated almost perfect performance for a multitude of proteins for which no meaningful templates were available -- hence, it was not doing homology modelling as it is generally understood, but ab initio protein structure prediction.

What I would support is that AlphaFold 2 does not solve the protein folding problem: how, as opposed to what to, a protein folds.