I'm glad for the Clojure community if this didn't exist before, but I'm pretty sure Lispers (ie Common Lispers) have written "entire" web apps in Lisp for quite a while[1].
For example, Kenny Tilton wrote a Lisp wrapper to qooxdoo on top of his data-flow library (Cells). The only time we need to write JS code now is for additional glue for widgets or functionality we haven't wrapped yet. And since it wraps qooxdoo, this means not writing (or needing to know) a lick of HTML/CSS. We just write Lisp. And we persist data to a triple store that "shapes" the Lisp/qooxdoo code at runtime.
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[1] I want to say "years" but I'm not sure how many people have used CL to write "entire" web apps.
For example, Kenny Tilton wrote a Lisp wrapper to qooxdoo on top of his data-flow library (Cells). The only time we need to write JS code now is for additional glue for widgets or functionality we haven't wrapped yet. And since it wraps qooxdoo, this means not writing (or needing to know) a lick of HTML/CSS. We just write Lisp. And we persist data to a triple store that "shapes" the Lisp/qooxdoo code at runtime.
</smug>
[1] I want to say "years" but I'm not sure how many people have used CL to write "entire" web apps.