Comment by jdeibele

I use lists. I found https://github.com/KrauseFx/twitter-unfollow which moves all of your follows to a private list. Then move people from the private list to a topic list.

I also use Tweetbot on my Mac, which allows me to filter retweets. That means I only see what people say. I do use another filter on my National Basketball Association list to block a certain keyword.

The downsides of Tweetbot is that it doesn't support everything that Twitter offers (polls, probably fleets, etc.) and is about $10.