but my friends who are tell me that's a lot of changes, and that experiments might change a few base pairs or proteins at a time. A lab leak theory doesn't explain how gain of function study resulted in so many mutations, unless they were blasting these viruses with radiation
Or explicitly creating chimeric coronaviruses, which has been the state of the are for some time. Here's https://pubmed.ncbi.nlm.nih.gov/26552008/ one of the sources of smoke on this, a 2015 paper co-authored by the Bat Woman (2nd to last author), the key sentence from the abstract:
Using the SARS-CoV reverse genetics system, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone.
Have you read the fine article? It cites more than a few papers.
Or explicitly creating chimeric coronaviruses, which has been the state of the are for some time. Here's https://pubmed.ncbi.nlm.nih.gov/26552008/ one of the sources of smoke on this, a 2015 paper co-authored by the Bat Woman (2nd to last author), the key sentence from the abstract:
Using the SARS-CoV reverse genetics system, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone.
Have you read the fine article? It cites more than a few papers.