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Comment by fighterpilot

> Calories in, calories out absolutely work.

Is this really true and known empirically? Could the body be better at accessing calories in some foods and not others?

Thought experiment: suppose I wrapped a small chocolate bar into airtight plastic, then I swallowed it. I have just swallowed 200 calories, but my body will access/process/burn 0% of it since it can't break down the plastic.

At least in this one (unrealistic) example, CICO is false.

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