I would advice to interpret the IFR reported by the Ioannidis paper with an extreme amount of caution. One of the authors criticized (which is quite an understatement) by Ioannidis went into a detailed rebuttal in [1]. A second thread [2] also gives a very detailed analysis of issues with the paper.
[1] https://twitter.com/GidMK/status/1376304539897237508 [2] https://twitter.com/AtomsksSanakan/status/137593538213983437...