Comment by bbeesley

It makes a lot more sense to ad block system wide than to expect every bit of software you use to implement extensions to allow you to do it. There are plenty of services like AdGuard and Lockdown, they can use the same lists that ublock uses, and you protect not just your browser but your email and everything else you use. Some routers will let you do something similar, and you can add a pihole to your network if your router won’t help.