I don't know why these studies keep getting funded.
Here is how they (generally) work: You take a mouse and cure it's Alzheimer's, right? Except mice don't live 70 years, and even if they did you can't wait 70 years for Alzheimer's mice to test drugs on. So you inject poison into the mouse's brain so it kindof has Alzheimer's like symptoms. Well, that's not even quite right, since you can't tell if a mouse has Alzheimer's like symptoms or just generalized brain damage (it's a mouse, you can't ask it if it can remember what year it is or what their kids names are, you can only see if they can remember which cup the cheese is under, well actually you can't even test that, just whether they behave like a healthy mouse would if it remembered, or some other really poor proxy for the sort of cognitive test you would use to diagnose Alzheimer's in humans) , but whatever, you have all these mice and someone is paying to inject them with poison so what can you do? Then you treat the poison damage with a drug, and get results ... but later it doesn't work on Alzheimer's in humans at all because human Alzheimer's isn't brain damage from poison injected into the brain.
Here is how they (generally) work: You take a mouse and cure it's Alzheimer's, right? Except mice don't live 70 years, and even if they did you can't wait 70 years for Alzheimer's mice to test drugs on. So you inject poison into the mouse's brain so it kindof has Alzheimer's like symptoms. Well, that's not even quite right, since you can't tell if a mouse has Alzheimer's like symptoms or just generalized brain damage (it's a mouse, you can't ask it if it can remember what year it is or what their kids names are, you can only see if they can remember which cup the cheese is under, well actually you can't even test that, just whether they behave like a healthy mouse would if it remembered, or some other really poor proxy for the sort of cognitive test you would use to diagnose Alzheimer's in humans) , but whatever, you have all these mice and someone is paying to inject them with poison so what can you do? Then you treat the poison damage with a drug, and get results ... but later it doesn't work on Alzheimer's in humans at all because human Alzheimer's isn't brain damage from poison injected into the brain.