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The molecular mechanism by which cholesterol causes heart disease is well understood, and atherosclerosis has been experimentally induced in every species of mammal ever studied by either feeding the animals a high cholesterol diet or knocking out genes related to LDL metabolism, and these results are consistent between hundreds of studies performed over the past 100 years. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525717/

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