Comment by bigmattystyles

Completely anecdotal, personal experience. It wasn't Accutane but when I was a pimply teen, in an effort to remedy the acne, I was prescribed doxycycline and another topical antibacterial ointment; in any case, I never had heartburn or experienced depression prior to that but a few months after starting those meds, both started. It's likely unrelated but whenever I read how crucial biomes are - I can't help but wonder. For the record, I preferred the acne.