I recall a researcher talking about previous attempts at creating coronavirus vaccines. How they resulted not in immunity, but in training the immune system to _over_ respond when a real infection came along.
> An early concern for application of a SARS-CoV vaccine was the experience with other coronavirus infections which induced enhanced disease and immunopathology in animals when challenged with infectious virus
I didn't dig deep enough to see if any experimental vaccines caused similar issues, but it definitely appears to be a concern.
So yeah, I'd be _very_ cautious with any homebrew vaccine. You might accidentally train your immune system to self destruct when you get exposed to a real SARS-CoV-2.
That said, I have little to no experience with biology, so it's entirely possible that radvac based vaccinations have already been demonstrated not to have this particular problem.
After a bit of digging I found this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335060/
> An early concern for application of a SARS-CoV vaccine was the experience with other coronavirus infections which induced enhanced disease and immunopathology in animals when challenged with infectious virus
I didn't dig deep enough to see if any experimental vaccines caused similar issues, but it definitely appears to be a concern.
So yeah, I'd be _very_ cautious with any homebrew vaccine. You might accidentally train your immune system to self destruct when you get exposed to a real SARS-CoV-2.
That said, I have little to no experience with biology, so it's entirely possible that radvac based vaccinations have already been demonstrated not to have this particular problem.