Vue and Svelte are both good. I'm not sure why create-react-app is a problem, but Vue can run without any scaffolding. I think it's worth just accepting that some scaffolding is needed for bundling, transpilation, etc.
There are dozens of alternatives like mithril - small in size, scope and community. You might miss a system for managing state in Mithril, as well as pre-built component libraries like Vuetify or react-bootstrap.
There are dozens of alternatives like mithril - small in size, scope and community. You might miss a system for managing state in Mithril, as well as pre-built component libraries like Vuetify or react-bootstrap.