I like using the layering with my Ergodox keyboard because it helps keep special characters I frequently use (parens, braces, brackets, etc) right under my fingers in a relaxes position. It alleviated a lot of finger strain I was feeling reaching for the keys (and reaching for shift especially) so frequently.
Though I do have a standard layout with the number/symbols row available as well.
Though I do have a standard layout with the number/symbols row available as well.