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Comment by atraac
I worked for two consultancies that basically created apps for multiple startups and we used .NET Core in almost all projects. I don't really have comparison because besides simple, personal Django projects I never had much experience with Python but I find .NET Core actually enjoyable(I come from Android Java/Kotlin world). I don't like the community which is, mostly still stuck in the enterprise(though that's changing alowly) and often feels like an MS cult, but otherwise, there's nothing bad I could really say about .NET. Especially when paired with Azure ecosystem, it's really easy do develop and deploy, it's really fast, easy to work with thanks to Entity Framework and stuff like LINQ, there's a lot of choice in libraries. Some are still stuck in .NET Framework(Windows) world, but most of Nugets already implement at least netstandard2.0 which allows you to use them with Core. In overall, especially now with Blazor becoming a thing, I'd recommend at least trying it out.