Also of note is tumor heterogenity. Not only are cancers different between cell origin and across different patients, cancer is not one uniform genetic entity even inside a single person.
Why? The cancer's ability to repair DNA mutations is crap, so different chunks of tumor can rapidly evolve different mutations.
You might be able to drug one portion of the tumor based on a fancy receptor/biomarker, but that tumor chunk will get outcompeted by a different cancer blob that doesn't express that.
Also of note is tumor heterogenity. Not only are cancers different between cell origin and across different patients, cancer is not one uniform genetic entity even inside a single person.
Why? The cancer's ability to repair DNA mutations is crap, so different chunks of tumor can rapidly evolve different mutations.
You might be able to drug one portion of the tumor based on a fancy receptor/biomarker, but that tumor chunk will get outcompeted by a different cancer blob that doesn't express that.