Malaria is probably going to be one of the hardest maladies to overcome. There was some promise with a vaccine, but it looks like that was fairly disappointing. The selective pressure is so high with malaria that sickle cell anaemia is a fairly common congenital disease that if one is homozygous for can be lethal in early age; conventional medicine has significantly increased life expectancy, but it's still fairly poor. Hopefully, it will be to the point where it can be controlled because the African continent has had its economies ravaged by it.
https://en.wikipedia.org/wiki/Malaria#Economic_impact