Safer for the operator? Sure. But certainly not for the device, if you're trying to keep it operating. An ATX power supply has 24 pins at 5 different voltage levels (plus any auxilliary power connectors for the GPU and drives, etc...), and motherboards are a lot less tolerant of spikes and transients than the PS on the other side.
Dealing with AC power isn't really that dangerous if you're careful.
Dealing with AC power isn't really that dangerous if you're careful.